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Adverse effects observed in trials to date include: Gastrointestinal symptoms nausea, vomiting, diarrhoea, and constipation (common with GLP-1 receptor agonists) Reduced appetite and weight loss , which may be excessive in some individuals Elevated heart rate , a concern noted with glucagon receptor agonism As with other incretin-based therapies, there is also a class-level signal for acute pancreatitis and gallbladder disease (including cholelithiasis and cholecystitis)

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ERK2 controls lipolysis by phosphorylating ADRB3 (at Ser247) and potentially other proteins, that regulate cAMP levels, such as ADCY6 and PDE4A/B 37

This is more common in the case of vitamin B12